queen victoria family tree ppt hemophilia

The male puppies produced from this mating with each have a 50:50 chance of being affected with hemophilia, and the females will each have a 50:50 chance of being a carrier. Hemophilia is most commonly propagated within a line when asymptomatic carrier females are bred to normal males. If an X chromosome carrying a normal gene for Factor VIII is represented as XH, and an X carrying the abnormal or hemophilic gene is represented as Xh then the different possibilities for clinical status (phenotype) and genetic makeup (genotype) can be represented as follows: Males having one abnormal gene are affected with hemophilia and will transmit that abnormal gene to all their daughters, but to none of their sons.įemales having one normal and one abnormal gene are asymptomatic carriers and will transmit the abnormal gene, on average, to one half of their sons and one half of their daughters. Males having one normal gene and females having two normal genes for Factor VIII are clear of the hemophilia A trait and will not transmit this defect to offspring. All females have two genes for Factor VIII, one inherited from dam and one from sire. All males have one gene for Factor VIII which they inherit from their dam. This form of inheritance is called sex-linked (or X-linked), recessive. The gene for Factor VIII is carried on the X chromosome and the presence of one normal gene is sufficient to prevent hemophilia. Abnormalities, or mutations, in the Factor VIII gene prevent the body's production of a normal, functional coagulation Factor VIII. The clotting factors are designated by roman numeral and Factor VIII (factor eight) is critical for normal blood clot formation. The bleeding tendency of Hemophilia A is caused by specific deficiency of a single clotting factor, Factor VIII. This article provides an overview of hemophilia, including information on inheritance pattern, clinical signs, and methods of identifying hemophilia affected and carrier dogs. Once hemophilia appears in a family, the defect can then be transmitted through many generations. In dogs, as in other species, the disease arises as the result of spontaneous mutation. Hemophilia A is the most common severe inherited coagulation disorder in animals and human beings.

Queen victoria family tree ppt hemophilia